Endocrine Abstracts

Introduction: For the last 2 years we have been giving regular diabetes education sessions in conjunction with our hospital school, based around maths skills. These went well, but we wanted to develop these further, making them more patient centred. We gained a grant from the Diabetes Research and Wellness Foundation and designed a 4 day programme with ‘The Puppet Project’ and ‘WAC arts’. This was done very much in collabaration with our hospital school who...

Currently, it has been established that obesity is a heterogeneous disease. There are metabolically healthy (MHO) and metabolically unhealthy obesity (MNHO) depending on the presence of cardiometabolic disorders. Potential factors that differentiate obesity into phenotypes include the gut microbiome and endocrine activity of adipose and muscle tissue. Purpose of the study was to compare intestinal microbiome and adipomyokine profile in patients with different obesity phenotype...

Background: Detection of MRI-negative ACTH-producing pituitary adenomas is a challenge inthe management of patients with Cushing’s disease. There are some data on theability of pituitary adenomas to accumulate 18F-fluorodeoxyglucose during the 18F-FDG positron emission tomography and computer tomography (18F-FDG PET/CT). Aim: To study the potential of using a standardized uptake value (SUV) and a tumor &...

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

Background: Primary aldosteronism (PA) accounts for a significant proportion of patients with hypertension. There has been a focus on ACTH in the pathogenesis of aldosterone secretion even with suppressed renin. With the link between psychological stress and cardiovascular disease as well as the association between anxiety and PA, there may be broader neurohormonal “stress” stimuli that modulate aldosterone production in PA patients, beyond the HPA axis. PA patients ...

We report a 64-year old female with a background of T2DM, renal transplantation requiring ongoing glucocorticoids, and treated toxic multinodular goitre. Following a traumatic T11 fracture and significant osteoporosis risk factors (female, postmenopausal, T2DM, glucocorticoid-use, sarcoidosis, and previous thyrotoxicosis), she was started on bisphosphonate therapy in 2012 with good concordance. Bone densitometry at the time demonstrated lumbar T...

A 68-year-old woman presented with a several month history of nausea, confusion and generalised weakness. In addition, she reported decreased appetite with significant weight loss. She did not report any convulsions, abdominal pain, palpitations, or diarrhoea. Significant past medical history included well-controlled T2DM, hypertension, vitamin D deficiency and GI reflux disease. Importantly, she had no history of renal disease. Relevant medications incl...

We present a case of a 56 year-old man diagnosed with systemic mastocytosis by the dermatologists on presentation with classical skin lesions, confirmatory bone marrow biopsy and a tryptase level 105 ug/L (NR 2-14). Further genetic testing confirmed KIT D816V mutation. DEXA bone densitometry at diagnosis revealed marked osteoporosis (Lumbar T score -3.7 (Z -3.5), Femoral Neck T score of -2.0 (Z -1.1). He had no history of low trauma fracture and no relev...

Background: Primary aldosteronism (PA) accounts for a significant proportion of patients with hypertension. There has been a focus on ACTH in the pathogenesis of aldosterone secretion even with suppressed renin. With the link between psychological stress and cardiovascular disease as well as the association between anxiety and PA, there may be broader neurohormonal “stress” stimuli that modulate aldosterone production in PA patients, beyond the HPA axis. PA patients ...

We report a 64-year old female with a background of T2DM, renal transplantation requiring ongoing glucocorticoids, and treated toxic multinodular goitre. Following a traumatic T11 fracture and significant osteoporosis risk factors (female, postmenopausal, T2DM, glucocorticoid-use, sarcoidosis, and previous thyrotoxicosis), she was started on bisphosphonate therapy in 2012 with good concordance. Bone densitometry at the time demonstrated lumbar T...